Sperm mediated gene transfer


Sperm-mediated gene transfer: applications and implications.

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Sperm mediated gene transfer
Zils M. reccomend Sperm mediated gene transfer
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Sperm-mediated gene transfer (SMGT) is a transgenic technique that transfers genes based on the ability of sperm cells to spontaneously bind to and internalize.

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Sperm-mediated gene transfer. - PubMed - NCBI

Sperm mediated gene transfer
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Description:Two barriers have been identified; the inhibitory factor in seminal fluid that prevents binding to foreign DNA molecules and a sperm endogenous nuclease activity that is triggered upon interaction of sperm cells with foreign DNA molecules. This binding and internalization of the DNA is not a random event. Therefore, the seminal fluid must be removed from the sperm samples by extensive washing immediately after ejaculation. Sperm-mediated gene transfer SMGT represents a novel set of technologies for animal or in the future, human genetic modification using the sperm as a vector, as opposed to more traditional Methods for sperm-mediated gene transfer. The major benefits of the SMGT technique were found to be its high efficiency, low cost and ease of use compared with other methods.

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Views: 2669 Date: 2018-08-04 Favorited: 44 favorites

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